Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism.

In response to growth factors, mTOR (mammalian target of rapamycin) has been identified as a central component of the signalling pathways that control the translational machinery and cell growth. Signalling through mTOR has also been shown to be necessary for the mechanical load-induced growth of ca...

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Detalhes bibliográficos
Main Authors: Hornberger, Troy A, Stuppard, Rudy, Conley, Kevin E, Fedele, Mark J, Fiorotto, Marta L, Chin, Eva R, Esser, Karyn A
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224227/
https://ncbi.nlm.nih.gov/pubmed/15030312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040274
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