Cardioprotective Stimuli Mediate Phosphoinositide 3-Kinase and Phosphoinositide Dependent Kinase 1 Nuclear Accumulation in Cardiomyocytes

The phosphoinositide-3-kinase (PI3K) / phosphoinositide dependent kinase 1 (PDK1) signaling pathway exerts cardioprotective effects in the myocardium through activation of key proteins including Akt. Activated Akt accumulates in nuclei of cardiomyocytes suggesting that biologically relevant targets...

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Main Authors: Rubio, Marta, Avitabile, Daniele, Fischer, Kimberlee, Emmanuel, Gregory, Gude, Natalie, Miyamoto, Shigeki, Mishra, Shikha, Schaefer, Eric M., Brown, Joan Heller, Sussman, Mark A.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692628/
https://ncbi.nlm.nih.gov/pubmed/19269295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.02.022
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