Rationally designed mutations convert de novo amyloid-like fibrils into monomeric β-sheet proteins
Amyloid fibrils are associated with a variety of neurodegenerative maladies including Alzheimer's disease and the prion diseases. The structures of amyloid fibrils are composed of β-strands oriented orthogonal to the fibril axis (“cross β” structure). We previously reported the design and characteri...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122421/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11880628/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052706199 |
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