Rationally designed mutations convert de novo amyloid-like fibrils into monomeric β-sheet proteins
Amyloid fibrils are associated with a variety of neurodegenerative maladies including Alzheimer's disease and the prion diseases. The structures of amyloid fibrils are composed of β-strands oriented orthogonal to the fibril axis (“cross β” structure). We previously reported the design and characteri...
Enregistré dans:
| Publié dans: | Proc Natl Acad Sci U S A |
|---|---|
| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2002
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122421/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11880628/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052706199 |
| Tags: |
Pas de tags, Soyez le premier à ajouter un tag!
|