Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

Although the residues that determine the preference of CYP2D6 (cytochrome P450 2D6) for compounds containing a basic nitrogen are well characterized, the contribution of other active site residues to substrate binding and orientation is less well understood. Our structural model of CYP2D6 identifies...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Flanagan, Jack U, Maréchal, Jean-Didier, Ward, Richard, Kemp, Carol A, McLaughlin, Lesley A, Sutcliffe, Michael J, Roberts, Gordon C K, Paine, Mark J I, Wolf, C Roland
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2004
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224184/
https://ncbi.nlm.nih.gov/pubmed/14992686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040062
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items