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Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions

The cytochromes P450 (CYPs) comprise a vast superfamily of enzymes found in virtually all life forms. In mammals, xenobiotic metabolizing CYPs provide crucial protection from the effects of exposure to a wide variety of chemicals, including environmental toxins and therapeutic drugs. Ideally, the in...

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Detalhes bibliográficos
Main Authors: Maréchal, J-D, Kemp, C A, Roberts, G C K, Paine, M J I, Wolf, C R, Sutcliffe, M J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268062/
https://ncbi.nlm.nih.gov/pubmed/18026129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707570
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