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p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1).
HIF-1 (hypoxia-inducible factor-1), a heterodimeric transcription factor comprising HIF-1alpha and HIF-1beta subunits, serves as a key regulator of metabolic adaptation to hypoxia. HIF-1 activity largely increases during hypoxia by attenuating pVHL (von Hippel-Lindau protein)-dependent ubiquitinatio...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1224165/ https://ncbi.nlm.nih.gov/pubmed/14992692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031299 |
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