Regulation of p53 by Hypoxia: Dissociation of Transcriptional Repression and Apoptosis from p53-Dependent Transactivation

Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike DNA damage, hypoxia does not induce p53-dependent cell cycle arrest, suggesting that p53 activity is differentially regulated by these two stresses. Here we report...

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Detalhes bibliográficos
Main Authors: Koumenis, Constantinos, Alarcon, Rodolfo, Hammond, Ester, Sutphin, Patrick, Hoffman, William, Murphy, Maureen, Derr, Jennifer, Taya, Yoichi, Lowe, Scott W., Kastan, Michael, Giaccia, Amato
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC99582/
https://ncbi.nlm.nih.gov/pubmed/11158315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.4.1297-1310.2001
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