Regulation of p53 by Hypoxia: Dissociation of Transcriptional Repression and Apoptosis from p53-Dependent Transactivation

Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike DNA damage, hypoxia does not induce p53-dependent cell cycle arrest, suggesting that p53 activity is differentially regulated by these two stresses. Here we report...

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Bibliografische Detailangaben

Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Koumenis, Constantinos, Alarcon, Rodolfo, Hammond, Ester, Sutphin, Patrick, Hoffman, William, Murphy, Maureen, Derr, Jennifer, Taya, Yoichi, Lowe, Scott W., Kastan, Michael, Giaccia, Amato
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2001
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99582/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158315/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.4.1297-1310.2001
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