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Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs.

Anthrax lethal toxin is the major cause of death in systemic anthrax. Lethal toxin consists of two proteins: protective antigen and LF (lethal factor). Protective antigen binds to a cell-surface receptor and transports LF into the cytosol. LF is a metalloprotease that targets MKKs [MAPK (mitogen-act...

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Hlavní autoři: Bardwell, A Jane, Abdollahi, Mahsa, Bardwell, Lee
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223970/
https://ncbi.nlm.nih.gov/pubmed/14616089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031382
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