Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase

Lethal factor, the principal virulence factor of Bacillus anthracis, inhibits mitogen-activated protein kinase (MAPK) signaling by proteolytically cleaving MAPK kinases. Edema factor, another component of anthrax toxin, is an adenylate cyclase, which increases intracellular cAMP. Inhibition of MAPK...

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Main Authors: Koo, Han-Mo, VanBrocklin, Matt, McWilliams, Mary Jane, Leppla, Stephan H., Duesbery, Nicholas S., Woude, George F. Vande
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC122471/
https://ncbi.nlm.nih.gov/pubmed/11867750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052707699
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