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Variations in aggrecan structure modulate its susceptibility to aggrecanases.
Proteoglycan aggregates and purified aggrecan from adult and fetal bovine cartilage and adult and neonatal human cartilage were subjected to in vitro degradation by recombinant aggrecanase-1 and aggrecanase-2. The ability of the aggrecanases to cleave within the aggrecan IGD (interglobular domain) a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1223671/ https://ncbi.nlm.nih.gov/pubmed/12859252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030609 |
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