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c-Myc potentiates the mitochondrial pathway of apoptosis by acting upstream of apoptosis signal-regulating kinase 1 (Ask1) in the p38 signalling cascade.

Cell transformation by growth-promoting oncoproteins renders cells extremely sensitive to apoptosis through an unknown mechanism affecting the mitochondrial pathway of apoptosis. We have shown previously that sensitization to apoptosis also correlated with the activation of the stress-activated prot...

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Autors principals: Desbiens, Katia M, Deschesnes, Réna G, Labrie, Mireille M, Desfossés, Yan, Lambert, Herman, Landry, Jacques, Bellmann, Kerstin
Format: Artigo
Idioma:Inglês
Publicat: 2003
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223429/
https://ncbi.nlm.nih.gov/pubmed/12646044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021565
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