Specificity of S'1 and S'2 subsites of human tissue kallikrein using the reactive-centre loop of kallistatin: the importance of P'1 and P'2 positions in design of inhibitors.

We have demonstrated that the S'(1) and S'(2) subsites of human tissue kallikrein (hK1) play determinant roles in the recognition and hydrolysis of substrates. The presence of serine at position P'(1) and arginine at P'(2) resulted in the best substrate, Abz-Ala-Ile-Lys-Phe-Phe-S...

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Autores principales: Pimenta, Daniel C, Fogaça, Sandro E, Melo, Robson L, Juliano, Luiz, Juliano, Maria A
Formato: Artigo
Lenguaje:Inglês
Publicado: 2003
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223352/
https://ncbi.nlm.nih.gov/pubmed/12578561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021952
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