Specificity of S'1 and S'2 subsites of human tissue kallikrein using the reactive-centre loop of kallistatin: the importance of P'1 and P'2 positions in design of inhibitors.

We have demonstrated that the S'(1) and S'(2) subsites of human tissue kallikrein (hK1) play determinant roles in the recognition and hydrolysis of substrates. The presence of serine at position P'(1) and arginine at P'(2) resulted in the best substrate, Abz-Ala-Ile-Lys-Phe-Phe-S...

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Détails bibliographiques
Auteurs principaux: Pimenta, Daniel C, Fogaça, Sandro E, Melo, Robson L, Juliano, Luiz, Juliano, Maria A
Format: Artigo
Langue:Inglês
Publié: 2003
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223352/
https://ncbi.nlm.nih.gov/pubmed/12578561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021952
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