Specificity of S'1 and S'2 subsites of human tissue kallikrein using the reactive-centre loop of kallistatin: the importance of P'1 and P'2 positions in design of inhibitors.

We have demonstrated that the S'(1) and S'(2) subsites of human tissue kallikrein (hK1) play determinant roles in the recognition and hydrolysis of substrates. The presence of serine at position P'(1) and arginine at P'(2) resulted in the best substrate, Abz-Ala-Ile-Lys-Phe-Phe-S...

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Detalhes bibliográficos
Main Authors: Pimenta, Daniel C, Fogaça, Sandro E, Melo, Robson L, Juliano, Luiz, Juliano, Maria A
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223352/
https://ncbi.nlm.nih.gov/pubmed/12578561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021952
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