The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin.

HFE, an atypical MHC class I type molecule, has a critical, yet still elusive function in the regulation of systemic iron metabolism. HFE mutations are linked to hereditary haemochromatosis type 1, a common autosomal recessive disorder of iron overload. Most patients are homozygous for a C282Y point...

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, Jian, Chen, Guohua, Pantopoulos, Kostas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2003
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223221/
https://ncbi.nlm.nih.gov/pubmed/12464008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021607
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