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Specificity and robustness in transcription control networks

Recognition by transcription factors of the regulatory DNA elements upstream of genes is the fundamental step in controlling gene expression. How does the necessity to provide stability with respect to mutation constrain the organization of transcription control networks? We examine the mutation loa...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Sengupta, Anirvan M., Djordjevic, Marko, Shraiman, Boris I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2002
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122321/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11854503/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.022388499
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