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Specificity and robustness in transcription control networks

Recognition by transcription factors of the regulatory DNA elements upstream of genes is the fundamental step in controlling gene expression. How does the necessity to provide stability with respect to mutation constrain the organization of transcription control networks? We examine the mutation loa...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Sengupta, Anirvan M., Djordjevic, Marko, Shraiman, Boris I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2002
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Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122321/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11854503/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.022388499
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