The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-gamma-mediated inhibition in human chondrocytes: requirement for Stat1 alpha, Jak1 and Jak2.

Interferon-gamma (IFN-gamma) inhibits the synthesis of the cartilage-specific extracellular matrix protein type II collagen, and suppresses the expression of the type II collagen gene ( COL2A1 ) at the transcriptional level. To further examine this mechanism, the responses of COL2A1 regulatory seque...

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Detalhes bibliográficos
Main Authors: Osaki, Makoto, Tan, Lujian, Choy, Bob K, Yoshida, Yasuhiro, Cheah, Kathryn S E, Auron, Philip E, Goldring, Mary B
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223055/
https://ncbi.nlm.nih.gov/pubmed/12223098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020928
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