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Leptin Receptor JAK2/STAT3 Signaling Modulates Expression of Frizzled Receptors in Articular Chondrocytes

OBJECTIVE: Differentiated articular chondrocytes express a functional isoform of the leptin receptor (LRb); however, leptin-LRb signaling in these cells is poorly understood. We hypothesized that leptin-LRb signaling in articular chondrocytes functions to modulate canonical Wnt signaling events by a...

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Hlavní autoři: Ohba, Seigo, Lanigan, Thomas M., Roessler, Blake J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997121/
https://ncbi.nlm.nih.gov/pubmed/20868760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2010.09.006
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