Protein ISGylation modulates the JAK-STAT signaling pathway

ISG15 is one of the most strongly induced genes upon viral infection, type I interferon (IFN) stimulation, and lipopolysaccharide (LPS) stimulation. Here we report that mice lacking UBP43, a protease that removes ISG15 from ISGylated proteins, are hypersensitive to type I IFN. Most importantly, in U...

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Autores principales: Malakhova, Oxana A., Yan, Ming, Malakhov, Michael P., Yuan, Youzhong, Ritchie, Kenneth J., Kim, Keun Il, Peterson, Luke F., Shuai, Ke, Zhang, Dong-Er
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2003
Materias:
Research Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC195994/
https://ncbi.nlm.nih.gov/pubmed/12600939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1056303
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