Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin.

Eukaryotic initiation factor (eIF) 2B is a guanine-nucleotide exchange factor that plays a key role in the regulation of protein synthesis. It is activated by insulin, serum and other agents that stimulate general protein synthesis. The largest (epsilon) subunit of eIF2B is a substrate for glycogen...

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Main Authors: Wang, Xuemin, Janmaat, Maarten, Beugnet, Anne, Paulin, Fiona E M, Proud, Christopher G
格式: Artigo
語言:Inglês
出版: 2002
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222905/
https://ncbi.nlm.nih.gov/pubmed/12133000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020677
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