Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha).

In insulin deficiency, increased lipid delivery and oxidation suppress skeletal-muscle glucose oxidation by inhibiting pyruvate dehydrogenase complex (PDC) activity via enhanced protein expression of pyruvate dehydrogenase kinase (PDK) isoform 4, which phosphorylates (and inactivates) PDC. Signallin...

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Bibliographic Details
Main Authors: Holness, Mark J, Bulmer, Karen, Gibbons, Geoffrey F, Sugden, Mary C
Format: Artigo
Language:Inglês
Published: 2002
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222844/
https://ncbi.nlm.nih.gov/pubmed/12099888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020754
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