Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone.

Liver contains two pyruvate dehydrogenase kinases (PDKs), namely PDK2 and PDK4, which regulate glucose oxidation through inhibitory phosphorylation of the pyruvate dehydrogenase complex (PDC). Starvation increases hepatic PDK2 and PDK4 protein expression, the latter occurring, in part, via a mechani...

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Hauptverfasser: Holness, Mark J, Bulmer, Karen, Smith, Nicholas D, Sugden, Mary C
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2003
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223128/
https://ncbi.nlm.nih.gov/pubmed/12435272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021509
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