Interference of poly(ethylene glycol)-lipid analogues with cationic-lipid-mediated delivery of oligonucleotides; role of lipid exchangeability and non-lamellar transitions.

Cationic liposomes are applied to transfer oligonucleotides (ODNs) into cells to regulate gene expression for gene therapeutic or cell biological purposes. In vivo, poly(ethylene glycol) (PEG)-lipid derivatives are employed to stabilize and prolong the circulation lifetime of nucleic acid-containing...

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Detalhes bibliográficos
Main Authors: Shi, Fuxin, Wasungu, Luc, Nomden, Anita, Stuart, Marc C A, Polushkin, Evgeny, Engberts, Jan B F N, Hoekstra, Dick
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222774/
https://ncbi.nlm.nih.gov/pubmed/12030844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020590
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