Formulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine)-poly(ethylene glycol) copolymers complexed to oligonucleotides

Antisense oligonucleotides (AOs) have been shown to induce dystrophin expression in muscles cells of patients with Duchenne Muscular Dystrophy (DMD) and in the mdx mouse, the murine model of DMD. However, ineffective delivery of AOs limits their therapeutic potential. Copolymers of cationic poly(eth...

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Detalhes bibliográficos
Main Authors: Sirsi, Shashank R, Schray, Rebecca C, Wheatley, Margaret A, Lutz, Gordon J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671478/
https://ncbi.nlm.nih.gov/pubmed/19351396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-3155-7-1
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