Phase behavior of cationic amphiphiles and their mixtures with helper lipid influences lipoplex shape, DNA translocation, and transfection efficiency.

Cationic lipids are widely used for gene transfection, but their mechanism of action is still poorly understood. To improve this knowledge, a structure-function study was carried out with two pyridinium-based lipid analogs with identical headgroups but differing in alkyl chain (un)saturation, i.e.,...

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Detalhes bibliográficos
Main Authors: Zuhorn, Inge S, Oberle, Volker, Visser, Willy H, Engberts, Jan B F N, Bakowsky, Udo, Polushkin, Evgeny, Hoekstra, Dick
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302298/
https://ncbi.nlm.nih.gov/pubmed/12324427
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