Plant-derived phenolic compounds prevent the DNA single-strand breakage and cytotoxicity induced by tert-butylhydroperoxide via an iron-chelating mechanism.

The protective effects of selected members from a series of caffeic acid esters and flavonoids were tested in various toxicity paradigms using U937 cells, previously shown to be sensitive to either iron chelators or bona fide radical scavengers or to both classes of compounds. It was found that all...

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Autors principals: Sestili, Piero, Diamantini, Giuseppe, Bedini, Annalida, Cerioni, Liana, Tommasini, Ilaria, Tarzia, Giorgio, Cantoni, Orazio
Format: Artigo
Idioma:Inglês
Publicat: 2002
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222553/
https://ncbi.nlm.nih.gov/pubmed/11988084
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