The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study.

Augmentation of superoxide levels has been linked to impaired relaxation in hypertension, diabetes and hypercholesterolaemia. Purified endothelial nitric oxide synthase (eNOS) generates superoxide under limited availability of 5,6,7,8-tetrahydrobiopterin (BH(4)). Thus alterations in endothelial BH(4...

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Bibliographic Details
Main Authors: Vásquez-Vivar, Jeannette, Martásek, Pavel, Whitsett, Jennifer, Joseph, Joy, Kalyanaraman, Balaraman
Format: Artigo
Language:Inglês
Published: 2002
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222439/
https://ncbi.nlm.nih.gov/pubmed/11879202
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