Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats.

Constitutive nitric oxide synthase (cNOS) with insufficient cofactor (6R)-5,6,7,8-tetrahydrobiopterin (H4B) may generate damaging superoxide (O2-). This study was designed to determine whether cNOS-dependent generation of O2- occurs in spontaneously hypertensive rats (SHR) before the onset of hypert...

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Detalhes bibliográficos
Main Authors: Cosentino, F, Patton, S, d'Uscio, L V, Werner, E R, Werner-Felmayer, G, Moreau, P, Malinski, T, Lüscher, T F
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC508731/
https://ncbi.nlm.nih.gov/pubmed/9525996
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