Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide.

The underlying mechanisms regulating the activity of the family of homodimeric nitric oxide synthases (NOSs) and, in particular, the requirement for (6R)-5,6,7,8-tetrahydro-L-biopterin (H(4)Bip) are not fully understood. Here we have investigated possible allosteric and stabilizing effects of H(4)Bi...

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Detalhes bibliográficos
Main Authors: Kotsonis, P, Fröhlich, L G, Shutenko, Z V, Horejsi, R, Pfleiderer, W, Schmidt, H H
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220911/
https://ncbi.nlm.nih.gov/pubmed/10698705
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