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The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain
Proteolytic processing of the amyloid precursor protein by β-secretase generates C99, which subsequently is cleaved by γ-secretase, yielding the amyloid β peptide (Aβ). This γ-cleavage occurs within the transmembrane domain (TMD) of C99 and is similar to the intramembrane cleavage of Notch. However,...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The National Academy of Sciences
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122196/ https://ncbi.nlm.nih.gov/pubmed/11805291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032395699 |
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