The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain

Proteolytic processing of the amyloid precursor protein by β-secretase generates C99, which subsequently is cleaved by γ-secretase, yielding the amyloid β peptide (Aβ). This γ-cleavage occurs within the transmembrane domain (TMD) of C99 and is similar to the intramembrane cleavage of Notch. However,...

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Detalhes bibliográficos
Main Authors: Lichtenthaler, Stefan F., Beher, Dirk, Grimm, Heike S., Wang, Rong, Shearman, Mark S., Masters, Colin L., Beyreuther, Konrad
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122196/
https://ncbi.nlm.nih.gov/pubmed/11805291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032395699
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