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Discrimination against purine–pyrimidine mispairs in the polymerase active site of DNA polymerase I: A structural explanation
We previously identified five derivatives of Klenow fragment DNA polymerase that have lower fidelity because of amino acid substitutions in the polymerase active site. One of these has alanine substituted for the invariant Glu-710, whose side chain interacts with the deoxyribose of the incoming dNTP...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122166/ https://ncbi.nlm.nih.gov/pubmed/11830658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032457899 |
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