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B Family DNA Polymerases Asymmetrically Recognize Pyrimidines and Purines
We utilized a series of pyrimidine analogues modified at O(2), N-3, and N(4)/O(4) to determine if two B family DNA polymerases, human DNA polymerase α and herpes simplex virus I DNA polymerase, choose whether or not to polymerize pyrimidine dNTPs using the same mechanisms they use for purine dNTPs....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3156867/ https://ncbi.nlm.nih.gov/pubmed/21761848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2006916 |
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