Discrimination against purine–pyrimidine mispairs in the polymerase active site of DNA polymerase I: A structural explanation

We previously identified five derivatives of Klenow fragment DNA polymerase that have lower fidelity because of amino acid substitutions in the polymerase active site. One of these has alanine substituted for the invariant Glu-710, whose side chain interacts with the deoxyribose of the incoming dNTP...

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Main Authors: Minnick, Dana T., Liu, Lixing, Grindley, Nigel D. F., Kunkel, Thomas A., Joyce, Catherine M.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC122166/
https://ncbi.nlm.nih.gov/pubmed/11830658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032457899
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