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Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades
Covalent modification cycles are ubiquitous. Theoretical studies have suggested that they serve to increase sensitivity. However, this suggestion has not been corroborated experimentally in vivo. Here, we demonstrate that the assumptions of the theoretical studies, i.e., irreversibility and absence...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The National Academy of Sciences
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122162/ https://ncbi.nlm.nih.gov/pubmed/11830657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022267399 |
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