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Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades
Covalent modification cycles are ubiquitous. Theoretical studies have suggested that they serve to increase sensitivity. However, this suggestion has not been corroborated experimentally in vivo. Here, we demonstrate that the assumptions of the theoretical studies, i.e., irreversibility and absence...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The National Academy of Sciences
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122162/ https://ncbi.nlm.nih.gov/pubmed/11830657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022267399 |
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