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Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades

Covalent modification cycles are ubiquitous. Theoretical studies have suggested that they serve to increase sensitivity. However, this suggestion has not been corroborated experimentally in vivo. Here, we demonstrate that the assumptions of the theoretical studies, i.e., irreversibility and absence...

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Main Authors: Ortega, Fernando, Acerenza, Luis, Westerhoff, Hans V., Mas, Francesc, Cascante, Marta
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2002
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC122162/
https://ncbi.nlm.nih.gov/pubmed/11830657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022267399
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