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Study of the structure-activity relationships for the pyrazinamidase (PncA) from Mycobacterium tuberculosis.

In an attempt to investigate the molecular basis of pyrazinamide hydrolysis by the PncA protein from Mycobacterium tuberculosis, we determined the pyrazinamidase activity of nine PncA mutants bearing a single amino acid substitution. Among them, three mutants (D8G, K96T and S104R) had virtually no a...

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Bibliografiske detaljer
Main Authors: Lemaitre, N, Callebaut, I, Frenois, F, Jarlier, V, Sougakoff, W
Format: Artigo
Sprog:Inglês
Udgivet: 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221589/
https://ncbi.nlm.nih.gov/pubmed/11171040
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