Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.

Amyloid beta-protein (Abeta) has been implicated as an early and essential factor in the pathogenesis of Alzheimer's disease. Although its cellular production has been studied extensively, little is known about Abeta clearance. Recently, insulin-degrading enzyme (IDE), a 110-kDa metalloendopept...

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Hlavní autoři: Chesneau, V, Vekrellis, K, Rosner, M R, Selkoe, D J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2000
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221388/
https://ncbi.nlm.nih.gov/pubmed/11023838
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