Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency.

Endothelial cells (EC) from diabetic BioBreeding (BB) rats have an impaired ability to produce NO. This deficiency is not due to a defect in the constitutive isoform of NO synthase in EC (ecNOS) or alterations in intracellular calcium, calmodulin, NADPH or arginine levels. Instead, ecNOS cannot prod...

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Detalhes bibliográficos
Main Authors: Meininger, C J, Marinos, R S, Hatakeyama, K, Martinez-Zaguilan, R, Rojas, J D, Kelly, K A, Wu, G
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221156/
https://ncbi.nlm.nih.gov/pubmed/10861247
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