A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction.

gp130 is the common signal-transducing receptor chain of interleukin (IL)-6-type cytokines. Here we describe, for the first time, a single amino acid substitution (Trp(666)-->Ala) in the membrane-proximal interbox1/2 region that abrogates activation of STAT (signal transducer and activator of tra...

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Main Authors: Haan, C, Hermanns, H M, Heinrich, P C, Behrmann, I
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221146/
https://ncbi.nlm.nih.gov/pubmed/10861237
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