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Inactivation of cysteine proteases by peptidyl epoxides: characterization of the alkylation sites on the enzyme and the inactivator.

Erythro peptidyl epoxides are selective inactivators of cysteine proteases. The alkylation site, both on the enzyme papain and on the epoxide itself, was characterized. The inactivation of papain with the peptidyl epoxide erythro benzyloxycarbonyl-Phe-Ala-epoxide was followed by total hydrolysis by...

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Bibliografische gegevens
Hoofdauteurs: Albeck, A, Kliper, S
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2000
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220824/
https://ncbi.nlm.nih.gov/pubmed/10657241
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