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Peptidyl cyclopropenones: Reversible inhibitors, irreversible inhibitors, or substrates of cysteine proteases?

Peptidyl cyclopropenones were previously introduced as selective cysteine protease reversible inhibitors. In the present study we synthesized one such peptidyl cyclopropenone and investigated its interaction with papain, a prototype cysteine protease. A set of kinetics, biochemical, HPLC, MS, and (1...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Cohen, Meital, Bretler, Uriel, Albeck, Amnon
פורמט: Artigo
שפה:Inglês
יצא לאור: Blackwell Publishing Ltd 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690718/
https://ncbi.nlm.nih.gov/pubmed/23553793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2260
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