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Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols
Hyperglycaemia, triose phosphate decomposition and oxidation reactions generate reactive aldehydes in vivo. These compounds react non-enzymatically with protein side chains and N-terminal amino groups to give adducts and cross-links, and hence modified proteins. Previous studies have shown that free...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1550308/ https://ncbi.nlm.nih.gov/pubmed/16671891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060019 |
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