Molecular determinants of the physicochemical properties of a critical prion protein region comprising residues 106-126.

Prion diseases are marked by the cerebral accumulation of conformationally modified forms of the cellular prion protein (PrP(C)), known as PrP(res). The region comprising the residues 106-126 of human PrP seems to have a key role in this conformational conversion, because a synthetic peptide homolog...

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Detalhes bibliográficos
Main Authors: Salmona, M, Malesani, P, De Gioia, L, Gorla, S, Bruschi, M, Molinari, A, Della Vedova, F, Pedrotti, B, Marrari, M A, Awan, T, Bugiani, O, Forloni, G, Tagliavini, F
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220454/
https://ncbi.nlm.nih.gov/pubmed/10432318
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