DNA polymerase beta: effects of gapped DNA substrates on dNTP specificity, fidelity, processivity and conformational changes.

Pre-steady-state kinetic analysis was used to compare the catalytic properties of DNA polymerase beta (Pol beta) for single-base gap-filling and regular duplex DNA synthesis. The rate of polymerization (kpol) and the apparent equilibrium dissociation constant of dNTP (Kd) were determined with single...

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Main Authors: Ahn, J, Kraynov, V S, Zhong, X, Werneburg, B G, Tsai, M D
格式: Artigo
語言:Inglês
出版: 1998
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1219323/
https://ncbi.nlm.nih.gov/pubmed/9512464
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