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Endoplasmic reticulum Ca2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell.

The role of intracellular Ca2+ in the proteolytic processing and intracellular transport of secretory granule proproteins was investigated by pulse-chase radiolabelling of isolated rat islets of Langerhans. The conversion of proinsulin was inhibited by depletion of medium Ca2+ with EGTA and by block...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Guest, P C, Bailyes, E M, Hutton, J C
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1997
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1218339/
https://ncbi.nlm.nih.gov/pubmed/9163336
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